Top 50 U.S. Venture Capital Investors in Medical Devices and Diagnostics

Investor Sum of Deals ($M) Year Founded Notable Portfolio Companies/Alumni Locations About
Domain Associates $921.15 1985 Fractyl, Tandem Diabetes Care, Obalon Princeton, NJ; San Diego; Philadelphia Domaine Associates focuses exclusively on the life sciences sector, with primary investment areas in medical devices, diagnostics, and pharmaceuticals. The firm prefers to be involved in a company’s first institutional financing round but will consider funding at other stages.
Versant Ventures $804.34 1999 Twelve Inc., Insulet, Second Sight Medical Products San Francisco; New York City; Minneapolis; Basel, Switzerland; Vancouver, BC Versant Ventures invests in companies at all development stages across the healthcare sector, with an emphasis on the discovery and development of novel therapeutics.
New Enterprise Associates $792.50 1977 Acclarent, Earlnes, CVRx Menlo Park, CA; San Francisco; Boston; Chevy Chase, MD; Timonium, MD; New York City; Mumbai New Enterprise Associates focuses on companies at all stages across both the technology and healthcare sectors. Within its healthcare practice, the firm invests in companies in the medical devices, biopharma, and healthcare services/IT spaces. 
Kleiner Perkins Caufield & Byers $685.15 1972 Apnicure, CardioDx, Zephyr Health Menlo Park, CA; San Francisco; Shanghai Kleiner Perkins Caufield & Byers focuses on the technology and life science industries, investing in companies in the consumer digital, enterprise digital, IoT/connected devices, digital health, and sustainability spaces. 
OrbiMed $680.15 1989 Acutus Medical, Glaukos, Proteus Digital Health New York City; San Francisco; Mumbai; Herzliya, Israel; Shanghai OrbiMed invests in healthcare companies at all stages of development. Its portfolio includes companies in the medical device, diagnostics, biopharmaceutical, health IT, and healthcare services sectors.
Johnson & Johnson Innovation - JJDC $647.46 1973 CVRx, ReVision Optics, Verb Surgical New York City Johnson & Johnson Innovation - JJDC focuses on consumer, pharmaceutical, global public health, and medical device companies at all stages. Within the medical device sector, it targets the areas of surgical oncology, obesity, osteoarthritis, osteoporosis, and cardiovascular.
Venrock $630.18 1969 Spirox, Peak Surgical, Reflexion Medical Palo Alto, CA; New York City; Boston Venrock's portfolio includes companies in both the technology and healthcare sectors. Within healthcare, the company invests in the diagnostics, medical device, and therapeutics spaces.
Morgenthaler $561.93 1968 Twelve Inc. Ardian, Holaira Palo Alto, CA; Boston; Boulder, CO Morganthaler Ventures has teams focusing on information technology, private equity, and life sciences. Within life sciences, it invests in medical device and biopharmaceutical companies with novel, disruptive technologies. Although the firm predominantly participates in Series A rounds, it is open to investing in later stages, with a total investment size of $12 million to $15 million per company.
Deerfield Management $527.53 1994 Endologix, SentreHEART, Acutus Medical New York City; Shanghai; Epalinges, Switzerland Deerfield focuses on the healthcare sector, investing in public healthcare securities and custom-designing transactions to accommodate long-term structured investments in both public and private healthcare companies.
Arboretum Ventures $519.85 2002 Cardiac Dimensions, Si-Bone, NxThera Ann Arbor, MI Arboretum Ventures specializes in the healthcare sector, including medical devices, diagnostics, healthcare services, and health IT. The firm prefers companies based in the Midwest.
De Novo Ventures $491.97 2000 Benvenue Medical, Pulmonx, Hansen Medical Saratoga, CA De Novo Ventures invests in medical device and biotech companies at all stages.
Aisling Capital $478.35 2000 Earlens, Lombard Medical, TransEnterix New York City Aisling Capital invests in public and private companies across the biopharma, consumer, diagnostics, medical device, and services sectors.
SV Health Investors $429.87 1993 Direct Flow Medical, CardioFocus, Endotronix Boston, San Francisco, London SV Health Investors focuses on the biotechnology, medical device, helathcare services, and digital health sectors.
Novo $429.64 1999 Apollo Endosurgery, Cianna Medical, iRhythm Copenhagen, San Francisco, Boston, London Novo Holdings, which is owned by the Novo Nordisk Foundation, invests in companies of any stage developing new drugs, new procedures for the diagnosis and control of diseases, medical devices and instruments, and industrial biotechnology. The firm's investments range from $5 million to $30 million per transaction, and it can also make follow-on investments.
InterWest Partners $419.10 1979 Obalon, Benvenue, Invuity Menlo Park, CA InterWest focuses on investing in early-stage healthcare and information technology companies. The firm prefers to fund development-stage companies but will also invest in early-stage companies with near-term ROI potential. It invests an average of $10 million to $15 million in the companies it supports.
Accuitive Medical Ventures $398.62 1999 Torax Medical, Respicardia, AxoGen Atlanta, GA; Amelia Island, FL Accuitive Medical Ventures invests in medical device companies that have a large target market, strong intellectual property, technology with clear benefit, a compelling business modle, a clear path to market, and multiple exit opportunities.
U.S. Venture Partners $377.11 1981 Apnicure, OncoMed, HeartFlow Menlo Park, CA U.S. Venture Partners invests across the consumer, enterprise, and healthcare industries. The firm looks for companies targeting markets of at least $500 million and up to more than $1 billion.
New Leaf Venture Partners $372.81 2005 Direct Flow Medical, Nx Stage, Aspire Medical New York City; San Mateo, CA New Leaf Venture Partners invests in companies across the biopharmaceutical, information convergence, biotechnology, and medical device sectors.
Aberdare Ventures $364.89 1999 Sonitus Medical, Elation EMR, MC10 San Francisco Aberdare Ventures invests from $1 million to $15 million in transformational healthcare companies.
Gilde Healthcare Partners $352.99 2001 CVRx, FlowCardia, Stat Diagnostica Cambridge, MA; Utrecht, The Netherlands Gilde Healthcare invests in digital health, diagnostics, medical device, therapeutic, and healthcare services companies across the U.S. and Europe.
TPG Biotech $342.19 1992 CardioDx, Tandem Diabetes Care, Novasom Boston; Austin, TX; Dallas Forth Worth, TX; Houston, New York City; San Francisco TPG Biotech invests across a range of industries, including healthcare.
Lightstone Ventures $337.32 2012 Claret Medical, SetPoint Medical, Earlens Menlo Park, CA; Boston; Dublin, Ireland; Singapore Lightstone Ventures invests in biopharmaceutical and medical device companies.
ARCH Venture Partners $328.41 1986 Ekos Corp., R2 Technology, Cytrellis Austin, TX; Chicago; Seattle; San Francisco; Europe Arch Venture Partners invests in the development of seed and early-stage advanced technology companies, including medical device and digital health companies.
MPM Capital $321.97 1996 23andMe, Astute Medical, Endologix Cambridge, MA; San Francisco MPM Capital invests in healthcare companies across all therapeutic areas.
Clarus Ventures $313.92 2005 Flowonix, Globus Medical, Sientra Cambridge, MA; San Francisco Clarus Ventures invests in public and private companies in the biotechnology, medical device, and diagnostics spaces.
Canaan Partners $311.51 1987 Chrono Therapeutics, EndoGastric Solutions, Glooko San Francisco; Menlo Park, CA; Westport, CT; New York City Canaan Partners invests across the healthcare and technology sectors.
Aperture Venture Partners $310.79 2002 Mako Surgical Corp., T2 Biosystems, Cardiac Dimensions New York City Aperture Venture Partners invests in medical device, pharmaceutical, healthcare IT, healthcare services, and diagnostics companies.
General Catalyst Partners $305.69 2000 Oceans Healthcare, Livongo, Fractyl Laboratories Cambridge, MA; New York City; Palo Alto, CA; San Francisco General Catalyst Partners invests across a range of industries, including healthcare.
Novartis Venture Funds $295.28 1996 Autonomic Technologies, Lemonaid Health, MyoPowers Basel, Switzerland; Cambridge, MA; Novartis Venture Fund invests in companeis across the biotechnology, biopharmaceutical, medical device, and diagnostics sectors in North America, Europe, Israel, and Asia/Pacific.
CHL Medical Partners $291.75 1997 SpineWave, Vascular Pathways, Valeritas Stamford, CT CHL Medical Partners invests in early-stage companies across the life sciences and healthcare services sectors. It prefers companies that address large, underserved markets, offer near-term revenue and profit growth, have the ability to attract top management, and have multiple exit options.
Split Rock Partners $291.14 2004 Cayenne Medical, Entellus Medical, Transcend Medical Eden Prairie, MN Split Rock Partners invests in companies across the technology and healthcare sectors.
Polaris Partners $268.21 1996 T2 Biosystems, Respicardia, Neuronetics Boston; San Francisco; Dublin, Ireland Polaris Partners invests in technology and healthcare companies at all stages. Its healthcare investments span the biotechnoloyg, medical device, diagnostics, and healthcare services segments.
Western Technology Investment $267.10 1980 Advanced Cardiac Therapeutics, Acumen, AirXpanders Portola Valley, CA Western Technology Investment invests in early- and mid-stage technology companies, including those in healthcare.
Three Arch Partners $266.58 1993 Neuronetics, Benvenue Medical, Tibion Bionic Technologies San Mateo, CA Three Arch Partners is no longer looking for new investments.
ProQuest Investments $266.50 1998 ACMI, Artemis, Concentric Medical Naples, FL ProQuest Investments invests in seed to late-stage healthcare companies. The company has special expertise in therapeutics.
Third Rock Ventures $265.48 2007 Taris, Corvia Medical, Cibiem Boston, San Francisco Third Rock Ventures invests in healthcare companies across sectors including medical devices, diagnostics, and personalized medicine. The firm prefers to be actively involved in the early stages of development.
Advanced Technology Ventures $262.19 1979 Cepheid, Gynesonics, Holaira Boston; Menlo Park, CA Advanced Technology Ventures focuses on the IT, cleantech, and healthcare sectors.
ONSET Ventures $248.71 1984 AneuRx, Endocardial Solutions, Spinal Concepts Menlo Park, CA Onset ventures invests in IT and medical technology companies.
Cross Creek Advisors $247.70 2006 Assurex Health, Cardica, Nx Stage Salt Lake City, UT Cross Creek Advisors invests in late-stage companies across sectors including healthcare.
Foundation Medical Management (now Flare Capital Partners) $244.18 2001 Welltok, HealthReveal, Circulation Boston Flare Capital Partners provides capital for early-stage and emerging healthcare technology companies.
Longitude Capital $239.38 2006 CardioDx, Amphora Medical, Twelve Inc. Menlo Park, CA; Greenwich, CT Longitude Capital invests in private and public biotechnology and medical device companies.
YuanMing Capital $227.00 WaveGuide, Mevion, BeiGene New York City, Beijing YuanMing Capital specializes in providing China-US cross border investments to healthcare companies, including those playing in the medical device, diagnostics, therapeutic, and healthcare services spaces
Greenspring Associates $224.95 2000 Teladoc, Trivascular, NeoTract Ownings Mills, MD; Palo Alto, CA Greenspring Associates invests across a number of sectors, including healthcare.
Sofinnova Partners $221.88 1974 Auris Medical, Actelion, BioClin Therapeutics Menlo Park, CA; San Diego Sofinnova specializes in clinical and late-preclinical investments in biopharmaceutical products.
Flagship Pioneering $216.43 2000 T2 Biosystems, Seventh Sense Biosystems, Avedro Cambridge, MA Flagship Pioneering invests across the therapeutic, health technology, sustainability, and other sectors.
Kaiser Permanente Ventures $215.25 1945 Proteus Digital Health, Omada, Big Health Oakland, CA Kaiser Permanente invests in healthcare companies and provides a pathway to Kaiser Permanente, the nation's largest integrated healthcare delivery system.
Altitude Life Science Ventures $212.40 2005 Illumina, Omniome, Ikaria Kirkland, WA Altitude Life Science Ventures invests in early-stage life science companies including those in the medical device, drug-delivery, and diagnostics sectors.
Lumira Capital $210.31 1988 BAROnova, Mako Surgical Corp., Endotronix Toronto; Boston; Montreal; Vancouver, BC; San Diego Lumira Capital invests in market-leading U.S. and Canadian companies in sectors including healthcare.

GE Ventures $204.97 2013 Acutus Medical, CardioDx, HeartFlow Menlo Park, CA; Boston; Chicago; Houston; Shanghai; Tel Aviv GE Ventures invests across the software, energy, advanced manufacturing, and healthcare industries.
5AM Ventures $203.48 2002 Biodesy, Chrono Therapeutics, Ceterix Orthopedics San Francisco, Boston 5AM Ventures invests across the life science sector, with a focus on biopharmaceuticals, drug-delivery technologies, and life science instruments. The firm prefers to participate in the first institutional funding round and has reserves for future investments.